Abstract
New complexes [Pd(HDMBG)2]Cl2·H2O, [PdL1]Cl2·0.5H2O and [PdL2]Cl2·1.5H2O (HDMBG: dimethylbiguanide, L1 and L2: ligands resulted from HDMBG, ammonia/hydrazine and formaldehyde template condensation) were synthesized and characterized. The features of complexes have been assigned from microanalytical, IR, UV–Vis and cyclic voltammetry data. The thermal transformations are complex processes according to TG and DTA curves including water and hydrochloric acid elimination, thermolysis processes leading to paracyanide formation as well as PdO decomposition, final product being palladium. Complexes were screened for their antimicrobial properties against some pathogenic Gram-positive and Gram-negative bacterial as well as fungal Candida albicans strains. The complexes exhibit specific antibacterial and/or antifungal activity, depending on their structure and the tested microbial strains. All complexes inhibit the microbial biofilm development on the inert substratum. It was also observed that PdCl2 complexation minimized their cytotoxic effect on the eukaryotic cells.
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