Thermal behavior and kinetic study of degradation for adamantan-2-one versus memantine hydrochloride

Abstract

Adamantan-2-one is an adamantane derivative used as a precursor for different adamantane-based pharmacologically active compounds. Adamantan-2-one and memantine hydrochloride were investigated in other of our previous published papers, as pure compounds and in binary mixtures with various excipients. The aim of our study is to determine the thermal behavior of adamantan-2-one, as well as the kinetic parameters that characterize the degradation process of this precursor. The employed analytical techniques were thermal analysis (TG/DTG/HF) and FTIR spectroscopy. The TG/DTG/HF curves were recorded in air at different heating rates: β = 5, 7, 10, 12 and 15 °C min−1, in respect of the ICTAC 2000 protocol regarding the kinetic analysis. The methods used for kinetic analysis of the thermal degradation process were isoconversional methods: Friedman and Flynn–Wall–Ozawa. Modified NPK method was used for determination of kinetic parameters.