Thermal behaviour and kinetic study of amygdalin

Abstract

The thermal methods of analysis are widely utilized in the study of stability and thermal decomposition of substances used in medicine, especially drugs. Kinetic studies have become a crucial point in thermal analysis, having as main purpose to determine the kinetic model of thermal decomposition and to calculate the parameters of the Arrhenius equation. The present work reports the study of thermal behaviour of amygdalin, active substance, and finding of the melting point based on the thermoanalytical curves, respectively, the determination of the kinetic parameters. The kinetic study regarding the amygdalin’s—active substance—thermal decomposition was performed under non-isothermal conditions and in a nitrogen atmosphere at five heating rates: 2.5; 5; 7.5; 10 and 15 °C min−1. The kinetic parameters of thermal decomposition process were obtained from TG/DTG curves using the following differential methods: Friedman isoconversional method, respectively, integral methods: Flynn–Wall–Ozawa method, Kissinger–Akahira–Sunose method, Starink method, and Li-Tang method.