Abstract
Studying the interaction of ultra-short pulse lasers with biological tissues and the corresponding mathematical modeling of possible thermal damage is of fundamental importance to the understanding of laser-tissue interaction for advancing surgical application of lasers. The objective of this paper is to review the existing techniques for thermal analysis of laser-tissue interaction. Different laser-tissue interaction mechanisms are discussed and the existing techniques for characterization of extent of damage are presented. A novel approach of using a focused laser beam from an ultra-short pulse laser source to ablate the subcutaneous tumors with minimal thermal effects is introduced. The extent of laser-induced damage is studied by determining the spatiotemporal expression patterns of Heat Shock Proteins. Keywords: Thermal ablation, Heat Shock Proteins, tumor removal, short-pulse laser, laser-tissue interaction, plasma mediated ablation, HSP70, HSP47, ablation modeling.
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