Therapy of rAd-p53 with chemotherapy for advanced oral carcinoma by selective intra-arterial infusion

Abstract

Purpose: To evaluate the safety and therapeutic effects of selective intra-arterial rAd-p53 infusion combined with chemotherapy for advanced oral carcinoma. Methods: Thirty-six patients with advanced SCC or ACC in oral region were subdivided into two groups. All patients underwent unilateral or bilateral retrograde selective catheterization of ECA. Through the arterial pumps, rAd-p53 combined with chemothereutic agents was administrated to group I (7 patients), rAd-p53 was administrated to group II (6 patients), and chemothereutic agents were administrated to group III (10 patients).