Abstract
Purpose: To evaluate the safety and curative effect of selective intraarterial rAd-p53 infusion combined with chemotherapy for locally advanced HNC, 23 patients were enrolled into a prospective clinical phase II study. Materials and Method: Twenty-three patients with locoregionally advanced SCC or ACC were subdivided into three groups. All patients underwent unilateral or bilateral retrograde selective catheterization of ECA. Through the arterial pumps, rAd-p53 combined with chemotherapeutic agents was administrated to group I (7 patients), rAd-p53 was administrated to group II (6 patients), and chemotherapeutic agents were administrated to group III Results: The complete response (CR) rate of group I (28.57%) was higher than that of group II (16.67%) and group III (10%).
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