THERAPY OF PERIODONTITIS WITH VASCULAR ENDOTHELIAL GROWTH FACTOR BASED ON HYDROGEL: IMMUNOHISTOCHEMICAL CHARACTERISTICS

Abstract

Regeneration of lost periodontal tissues is the ultimate goal of periodontal treatment. One of the promising approaches to stimulating periodontal regeneration is the use of hydrogels and various growth factors that contribute to the colonization of the scaffold with fibroblast populations, followed by the formation of mature connective tissue of the periodontal ligament. Patients with chronic generalized periodontitis of mild and moderate severity (n=70, age 49-69 years) were treated in the Department of maxillofacial surgery of the UKB No. 4. Treatment was carried out with a preparation from a complex of bioresorbable carbohydrates and recombinant human vascular endothelial growth factor (VEGF-A). The biopsy material was taken immediately before the introduction of the drug into the periodontal pocket and 14 days after the procedure. Prior to treatment, pronounced chronic inflammation with a predominance of lymphocytes, moderate edema and divergence of the fibers of the stromal component were noted in the gum preparations, signs of chronic moderate active inflammation were observed. After treatment, collagen fibers constructed from type III collagen and type I collagen were found in the structured fibers of the intercellular substance, which is characteristic of the formed connective tissue. Thus, the therapy of chronic periodontitis with a hydrogel with VEGF-A is a promising direction for further research, since it has the potential to influence not only stimulating the regeneration of periodontal tissues, but also the effect of local anti-inflammatory treatment.