Abstract
Chronic kidney disease (CKD) is a common complication of diabetes mellitus and besides vascular nephropathy the most common cause of kidney failure (CKD G5). Along with an increase of the prevalence of diabetes the number of patients with diabetes and CKD will rise. General knowledge of the interactions between diabetes and CKD are essential for a safe and effective therapy. Appropriate glycemic control in patients with diabetes is important to prevent progression of CKD and hereby improve cardiovascular complications, quality of life and reduce mortality. However, many antidiabetics need to be dose-adjusted in CKD or should not be used in existing or progressive CKD, especially in patients with CKD G5, whereas insulin therapy is suitable for patients undergoing dialysis. However, some orally administered glucose-lowering agents can be safely used in these patients. This review provides an overview of the use and goals of diabetes therapy in the presence of CKD.
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