Therapeutic Potential of Schiff and Mannich Bases of 2-Substituted Benzimidazole Analogues

Abstract

Heterocyclic scaffolds reveal extensive biological profiles, and several drugs were employed therapeutically which possess heterocyclic framework. Likewise, 2-substituted benzimidazoles play a significant role in novel drug development. In addition, Mannich and schiff base derivatives of benzimidazole acknowledged them as favorable anti-inflammatory, antimicrobial, anticancer, anthelmintic, antiviral scaffolds. Schiff bases in innumerable organic reactions show affirmative catalytic activity. The current scenario also emphasizes the spectacular activity displayed by schiff bases in the biochemical, coordination and analytical industry. Similarly, aminoalkyl reactions are revealed by mannich bases as they enclose amino alkyl chain which is imperative for its therapeutic action. Mannich bases are the products of nucleophilic addition reaction with the elimination of hydrogen atom of the amine radical for its biological venture. From the latest era, the efficacy of mannich bases as ligands and in the petroleum and leather industry were perceptible. The entire review expounds the therapeutic profile of mannich and schiff bases of 2-substituted benzimidazoles as competent biologically dynamic hybrids. Neoteric analogues of mannich and schiff bases of 2-substituted benzimidazoles with their patents in diverse fields have also been summarized.