Abstract
Abstract Purpose Vascular endothelial growth factor‐A (VEGF‐A) has recentlybeen recognized as an important neuroprotectantin the central nervous system. Given its positionas an anti‐angiogenic target in the treatment ofhuman diseases, understanding the extent of VEGF’srole in neural cell survival is paramount. Methods We have examined if VEGF‐A is necessary and sufficient for retinal neuroprotection in a model of ischemia‐reperfusion injury. Results VEGF‐A effects on neurons have been documented in several experimmental systems, including now, the retina. VEGF‐A's effects are likley mediated by direct signaling in neurons via VEGFR2. Conclusion These findings have implications for both neural pathologies and for the use of potent VEGF‐A antagonists in chronic ocular vascular diseases, such as diabetic retinopathy. Translateability of these animal findings to patients, and potential next steps will be discussed. Commercial interest
Published Version
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