Abstract
Objective To explore the therapeutic effects of HBO coupled with thioctic acid in the treatment of diabetic peripheral neuropathy (DPN). Methods Ninety-two patients with DPN were randomly divided into the HBO group and the ALA group, each consisting of 46 patients. The patients in the ALA group received routine hypoglycemic therapy and intravenous infusion of thioctic acid, while the patients in the HBO group were supplemented with HBO in addition to the above routine treatment. EMG was used to detect motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV), latency and response wave amplitude. Results After treatment, it could be seen that MNCV[nervus peroneus communis of HBO group, before treatment: (28.74±5.45)m/s, after treatment: (36.20±1.87)m/s] was accelerated, latency was shortened and wave amplitude was elevated, with statistical significance(P<0.05). It was quite noticeable that SNCV was accelerated, and wave amplitude was increased, also with statistical significance(P<0.05). Regarding the treatment results, the HBO group was superior to the ALA group, and statistical significance could be noticed, when comparisons were made between them(P<0.01). Conclusions HBO coupled with drug therapy could produce certain cumulative effects and effectively alleviate incidence of demyelination and axonal degeneration. So, this treatment method could improve the symptoms of patients with DPN, and facilitate quick recovery of peripheral nerve conduction. Key words: Hyperbaric oxygen; Diabetic peripheral neuropathy; Nerve conduction
Published Version
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