Abstract
Objective To evaluate the therapeutic effect of bilevel positive airway pressure ventilation (BiPAP) on overlap syndrome (OS) complicated with respiratory failure.Methods PubMed,Medline,Wanfang Data,CNKI and VIP were searched for the randomized controlled trials (RCT) of the therapeutic effect of BiPAP on overlap syndrome complicated with respiratory failure from the date of establishment of the databases to June 2012.The bibliographies of the in-cluded studies were searched too.The extracted data were analyzed by Review Manager 5.Results A total 6 trials(273 patients) were discovered.Meta-analyses showed that standard therapy plus BiPAP,compared with standard therapy alone,can improve PaO2 and PaCO2 (WMD =19.75,95％ CI 18.43 to 21.07 and WMD ＝-12.13,95％ CI-13.72 to-10.54,respectively).Conclusions The evidence shows standard therapy plus BiPAP can improve PaO2 and PaCO2 of overlap synd-rome complicated with respiratory failure.The clinicians should recommend it.Because of the limitations of the included studies,more large-sample and high-quality RCT are required. Key words: Bilevel positive airway pressure ventilation; Overlap syndrome; Respiratory failure
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