Therapeutic effects evaluation of vitamin E alone and in combination with ranitidine in stress – induced gastric ulcers in rats

Abstract

It is noteworthy to examine the morphologic and biochemical efficacies of vitamin E, and its combination with a histamine receptor type 2 blocker on stress gastric ulcers. Animals were divided into (6) groups; group 1 (normal control), group 2 (Cold – restraint stress; CRS), group 3 (ranitidine 20 mg/kg), group 4 (vitamin E 100 mg/kg), group 5 (ranitidine 10 mg/kg + vitamin E 50 mg/kg ), group 6 (ranitidine 5 mg/kg + vitamin E 50 mg/kg ). Rats received treatment orally for 7 consecutive days beginning 1 h after induction of the gastric injury . They were sacrificed for assessment of stomach damage using body weight loss, macroscopic changes, oxidative stress markers (MDA stomach content and SOD enzyme activity). Present findings showed that the combined treatment of vitamin E and ranitidine is dose-dependent, and significantly much more effective in management of stress-induced lesions than using vitamin E alone, which caused remarkable body weight decrease.