Moringa (Moringa oleifera) Leaves' Extract and Linseed (Linum usitatissimum) Oil Ameliorate Piroxicam Induced Gastric Ulcers in Male Rats

Abstract

Gastric ulcer is a standout amongst the most significant gastrointestinal disorders affecting human worldwide. An extraordinary interest should be given to find natural medications to treat this disease. Plant extracts are more favored because of their wide safety margins and less or no adverse health impacts. The present study was conducted to assess the antiulcer activities of hydroethanolic extract of moringa leaves (500mg Kg BW) and linseed oil (0.3mL/ Kg BW) on piroxicam (30 mg Kg BW) induced gastric ulcers in Wister albino rats. Forty five adult male albino rats were allocated into five equal (9 each) groups designated as negative control, piroxicam, ranitidine, moringa and linseed oil groups. The results revealed that administration of piroxicam in a single oral dose induced gastric ulcers in rats, decrease in body weights (187.50±10.51g) and increase in gastric juice (1.64±0.24mL) with altered hematological, biochemical and histological findings. Meanwhile, oral administration of ranitidine, Moringa oleifera and linseed oil amelioratedthe ulcerogenic effect of piroxicam with curative ratios of 100, 97.5 and 100%, respectively. From the previous findings we concluded that hydroethanolic extract of moringa leaves and linseed oil were effective treatments of piroxicam induced gastric ulcer in rats. Antiulcerogenic effect of moringa and linseed oil may be attributed to their anti-inflammatory and antioxidant properties.