Abstract
[Purpose]Although physical activity is required to prevent or ameliorate osteoporosis, medicine prescription should precede it, since it may be limited in severe osteoporosis patients. Furthermore, osteoporosis has a great effect on physical activity disorders that accompany fractures and pain, and therefore, research on treatment or prevention to decrease the number of patients is required. The purpose of this study was to discover candidate substances from natural products with an effective pharmacological action and to prepare basic data to help patients.[Methods] To prepare the osteoporosis model, ovariectomy (OVX) was performed using surgical methods. The prepared prescription [Shinkiwhan (SKH), a Korean medicine] was administered orally at a dose of 210 mg/kg/day for 8 weeks. After completion of the animal experiment, the bone mineral density (BMD) was analyzed using double-energy X-ray absorptiometry. The analysis of the effect of drugs on bones was performed using histological analysis and immunostaining.[Results] SKH increased the BMD in the OVX rats. Furthermore, SKH significantly increased the expression of osteoprotegerin and downregulated receptor activator of nuclear factor kappa B ligand and phosphorylation of c-jun N-terminal kinases in the bones of the OVX model.[Conclusion] Our findings suggest a protective effect of SKH against BMD loss in the OVX model.
Highlights
Physical activity is effective in preventing and treating diverse diseases
SKH inhibits the loss of bone mass in OVX rat model
SKH regulates the glycosaminoglycan in OVX rats
Summary
Physical activity is effective in preventing and treating diverse diseases. Westernized diets, sedentary lifestyles, and an irregular physical activity are increasing the incidence of disease in modern people. Older people and postmenopausal women have an increased incidence of osteoporosis due to their inactive lifestyle. Osteoporosis is a representative disease in which bone dysfunction is characterized by a bone mass decrease and an abnormal bone microstructure[1]. According to the National Health & Nutritional Examination Survey, the prevalence of osteoporosis in the United States is estimated to be about 5 million people[2,3]. The prevalence rate among women who are over 50 years of age is rapidly increasing worldwide[4]. It is urgent to diagnose osteoporosis, recognize the need for prevention and treatment, and find a treatment solution
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