Abstract
Metoclopramide is a dopamine antagonist that is used in gastro esophageal disease and enteritis in adults and pediatric. The major side effects are extrapyramidal symptoms. They appear as dystonic movements. These are more common in children and young adults, especially in females. This retrospective descriptive study was conducted in Misurata Medical Center. It is aimed to draw attention to the frequent occurrence of metoclopramide-induced side-reactions. We studied the files of 45 patients who had been exposed to this reaction between the years of 2006 to 2008. Different dosage form of metoclopramide found to induced this acute reaction. Dystonia was occurred in 18 (40%) children who received drops, 10 (22%) patients received injection, and 6 (13.33%) children received syrup, while one patient received a tablet. The other children had received two dosage forms as injection with drops, syrup or suppository. All 45 children were treated intravenously with a single dose of diazepam. Young children especially females are more susceptible to dystonic reactions form metoclopramide. Our study indicates that diazepam is effective drug to abolish this adverse reaction.
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