Therapeutic applications of recent advancements in insight regarding mechanisms of development of Anorexia Nervosa: implications in the management and development of biomarkers for early detection besides avoidance of neonatal malformations-A Short C

Abstract

Earlier we have reviewed regarding how patients of AN who present with primary/secondary hypothalamic amenorrhoea were markedly recalcitrant to any forms oftreatment besides deficiency in reward appreciation .Furthermore we concentrated on the pathophysiology of obesity along with its association with type2 diabetes mellitus( T2DM), besides non-alcoholic fatty liver disease(NAFLD)along with other co-morbidities, like Heart Failure, adiposity ,Metabolic Syndrome role of Gut Microbiot/besides role of pro as well as prebiotics, with Faecal microbiota transplantation(FMT) for their treatment. Here we have focused on the latest research carried out in an eating disorder called Anorexia Nervosa (AN) which we had earlier reviewed in association with hypothalamic amenorrhea as a psychiatric condition correlated with extreme anorexia, besides excessive exercise occasionally that usually brought young girls to us with amenorrhea. It had been an understood condition that was markedly resistant to any treatment. Extensive research carried out recently has revealed its association with other psychiatric conditions like depression, anxiety as well as PTSD along with altered nutrition profile with lower fiber intake thus correlated with lower CRP, whereas that with high saturated Fatty Acids (FA) with greater CRP as seen with Mediterranean diet that we commonly advocate for obese patients. Here we further detail how these advancement aid in treating such patients with the knowledge that the pathophysiology behind the development of these disorders lies in the alterations in various proinflammatory cytokines besides chemokines in AN, thus the association of inflammation besides neuroinflammation explaining the coexistence of psychiatric disorders in AN. These insights aid in planning innovative treatments for such disorders besides ensuring a smooth marriage, pregnancy and child birth. FMT might aid in treating patients that are markedly resistant to any treatment.