Abstract
Recently, a wide range of nanotechnologies has been approached for material modification by realizing the fact that the extracellular matrix (ECM) consists of nanoscale components and exhibits nanoscale architectures. Moreover, cell-cell and cell-ECM interactions actively occur on the nanoscale and ultimately play large roles in determining cell fate in tissue engineering. Nanomaterials have provided the potential to preferentially control the behavior and differentiation of cells. The present paper reviews the need for nanotechnology in regenerative medicine and the role of nanotechnology in repairing, restoring, and regenerating damaged body parts, such as blood vessels, lungs, and the heart.
Highlights
Regenerative medicine holds great promise for restoring the normal, healthy functions of human tissues after damage
A wide range of nanotechnologies for material modification has been approached by realizing the fact that the extracellular matrix (ECM) consists of nanoscale components and exhibits nanoscale architectures
Cell-cell and cell-ECM interactions actively occur on the nanoscale and play large roles in determining cell fate [5]
Summary
Regenerative medicine holds great promise for restoring the normal, healthy functions of human tissues after damage. Engineered biomaterial scaffolds with biological functionalization through cell seeding have been widely used to regenerate healthy tissues for replacement. The current review is focused on the needs of nanotechnology in developing tissue engineered scaffolds and the role of nanotechnology in improving tissue growth and function or inhibiting abnormal cell proliferation for major organs found in both the pulmonary and cardiovascular systems.
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