Abstract
Background: Fluorescent laparoscopic imaging of primary colorectal tumours and lymph node metastases would potentially facilitate intra-operative stratification of surgical resections and improve patient outcomes. Nanoparticulate platforms offer many advantages in terms of intra-operative imaging and biosensing for diagnostic purposes. Nanoparticles can be loaded with diverse reagents and then addressed to the correct tissue provided a specific biomarker molecule exists to which an antibody or Affimer (artificial binding protein) can be developed. We aimed to develop a fluorescent silica nanoparticles targeted against colorectal cancer (CRC) using an anti-carcinoembryonic antigen (CEA) Affimer (Aff).
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