Abstract
It is not understood how the HIV-1 retrovirus selects it genomic RNA (gRNA) for packaging into virions from among the multitude of cellular RNA molecules in the cytoplasm of infected cells. Under in-vitro conditions, the Gag proteins of HIV-1 have only a very weak specific binding affinity for the RNA Ψ sequence, which has been shown to be the key recognition label of genomic RNA. In addition, the cellular gRNA concentration is very low yet HIV packages gRNA with high fidelity. We present a numerical model for kinetic HIV-1 gRNA selection that is based on fusion of precursor buds followed by gRNA dimerization.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
