Abstract
How centrosomes control their size and growth, despite continuous turnover in their component parts, is a longstanding question. Recent studies suggest that size control of centrosomes is achieved through the depletion of a limiting subunit pool in the cytoplasm. While the limiting pool model ensures centrosome size scaling with cell size, it does not ensure robust size control of a pair of centrosomes in the presence of stochasticity. Here we present a mathematical model for centrosome size control via localized assembly and distributed disassembly of the pericentriolic matter (PCM) in a limiting cytoplasmic pool.
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