Abstract
The diffusional transport of drugs across a membrane under the influence of hydrostatic (or osmotic) flow is described. The physical model consists of a bulk aqueous phase with a diffusion layer followed by a heterogeneous (lipid/aqueous) compartment and a perfect sink. The steady-state rate of change of the total drug concentration in the bulk aqueous phase is in the general form of a first-order equation useful for the evaluation of experiments. Computations are made for different cases in simulation of the in situ absorption of drugs in animals when the tonicity of the drug solution is varied. Several limiting models are mathematically deduced from the more general approach.
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