Abstract
Multicompartment diffusional models for the absorption of neutral, acidic, basic, and amphoteric drugs were investigated. The general model consisted of a bulk aqueous phase, an aqueous diffusion layer,n-compartments of homogeneous and heterogeneous phases, and a perfect sink. With the mathematical techniques reported previously, equations were derived in general terms for the nonsteady- and steady-state periods. Utilizing the steady-state diffusion efficiency function of the barrier systems, the first-order rate constants for various examples of two- and three-compartment models were obtained from the general model and some computations were given. Various sets of in situ experimental rat data have been analyzed by means of the different models. These include the intestinal, gastric, and rectal absorption of sulfonamides and barbituric acid derivatives. Self-consistent dimensional constants and diffusion coefficients were arrived at and the correlations obtained with the models have been found to be generally satisfactory.
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