Abstract

The standard formulation of Wave Intensity Analysis (WIA) assumes that the flow velocity (U) in the conduit is $\ll$ the velocity of propagation of waves (c) in the system, and Mach number, M=U/c, is negligible. However, in the large conduit arteries, U is relatively high due to ventricular contraction and c is relatively low due to the large compliance; thus M is > 0, and may not be ignored. Therefore, the aim of this study is to identify experimentally the relationship between M and the reflection coefficient in vitro. Combinations of flexible tubes, of 2 m in length with isotropic and uniform circular cross sectional area along their longitudinal axes, were used to present mother and daughter tubes to produce a range of reflection coefficients. An approximately semi-sinusoidal pulse was generated at the inlet of the mother tube using a syringe pump, first in the condition of initial velocity, U 0 =0, and when U 0 >0 with steady flow to superimpose the pulse. Pressure (P) and Velocity (U) were measured in the mother tube, wave speed was determined using the foot to foot and PU-loops methods. The theoretical reflection coefficient, R t at M=0, has been compared to the experimental reflection coefficient, R at M>0, which was determined as dP-/dP+ as calculated using WIA. The function R(M) changes significantly with the geometrical and mechanical features of the connected tubes. In our experiments, R increased significantly with small values of M In the range of M=0-0.02, R increased by 4-36%. Therefore, we conclude that M significantly affects the magnitude of reflections.

Highlights

  • Arterial reflected waves play an important role in determining the features of the arterial pressure waveforms, including systolic pressure [1, 2]

  • The magnitude of reflected waves can be quantified by means of the reflection coefficient; i.e. the ratio between the backward to forward components of the pressure waveform or of the wave intensity

  • The aim of the present work is to determine the effect of M on the reflection coefficient in flexible tubes in vitro

Read more

Summary

Introduction

Arterial reflected waves play an important role in determining the features of the arterial pressure waveforms, including systolic pressure [1, 2]. The magnitude of reflected waves can be quantified by means of the reflection coefficient; i.e. the ratio between the backward to forward components of the pressure waveform or of the wave intensity. This parameter is normally assumed to be independent of the mean value of blood velocity in the artery. To derive the standard WIA formulation the blood velocity is assumed to be

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call