Abstract
The muscle work test (Ingle, 1944) has proven to be a sensitive and reliable procedure for the bio-assay of adrenal cortex extracts and steroids which affect carbohydrate metabolism. There is indirect evidence that the early loss of muscular responsiveness in the adrenalectomized animal is due to depletion of carbohydrate in the tissues and body fluids: (1) “Fatigue” of the stimulated muscle in the adrenalectomized rat is associated with hypoglycemia; (2) There is a close parallelism between the relative potencies of adrenal cortical extracts and steroids as bioassayed by the muscle work test and by the liver glycogen deposition test (Pabst, et al., 1947); and (3) It was shown by Ingle and Lukens (1941) that the intravenous administration of glucose to the “fatigued” adrenalectomized rat gave a temporary restoration of ability to work. The objective of the present study was to determine the effect of continuously administered glucose upon the ability of the adrenalectomized rat to continue working in resp...
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