Abstract
Anise oil, anethole, and several related compounds inhibit the deposition of glycogen in the livers of fasted, adrenalectomized rats by adrenal cortical extract. This effect is reversed by increased levels of adrenal extract. Anethole blocks the effect of adrenal cortical hormones in reducing insulin sensitivity of adrenalectomized rats. Adrenal hypertropy of unilaterally adrenalectomized rats is increased by anethole. It is postulated that these compounds compete for an active carbohydrate intermediate formed during glycogenesis. The possible role of β-glucuronidase is also pointed out.
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