Abstract
The vitreous body supports the retina, and is probably necessary for the maintenance of the clarity of the lens. Via anomalous posterior vitreous detachment (PVD) vitreoretinal pathology can have devastating consequences for visual function, and removal of pathological vitreous by vitrectomy is a common surgical procedure. This chapter discusses the anatomy, and molecular organization of the vitreous, as well as its development and aging changes. The vitreous is optically homogenous when examined in vivo with the slit lamp or by dark-field microscopy, in enucleated eyes. Aging results in structural changes in the vitreous, as well as characteristic alterations in the strength of vitreoretinal adhesion. Aging results in alterations in the strength of vitreoretinal adhesion that characteristically are unevenly distributed across the vitreoretinal interface. In the posterior part of the eye, there is a progressive weakening of the vitreoretinal adhesion. In the anterior part of the eye, increasing age is associated with remarkable changes in the vitreal base.
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