Abstract
Cyclin-dependent kinase 5 (Cdk5) is a member of cyclindependent kinase family without the ability of cell cycle control. In the initial stage of research history, Cdk5 was believed to respond for the development of nervous system. However, more and more evidence identifies the expressions and physiological functions of Cdk5 in extra-neuronal tissues. This article introduces readers some recent findings which demonstrate what roles that Cdk5 plays in different tissues and how Cdk5 changes to involve the formation of diseases. In addition to the physiological and pathological roles of Cdk5, the possibility of Cdk5 which becomes a drug target for treating diseases is also discussed in this article.
Published Version
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