Abstract
The vascular SIRTainty.
Highlights
It is of note that at early to middle stages of atherosclerosis and advanced age, endothelial nitric oxide (NO)-synthase (eNOS) protein level in the vasculature is not decreased and even upregulated[6,7]
The relationship between SIRT1-eNOS signaling and atherosclerosis has been implicated recently by Chen and colleagues[11], who show that SIRT1 level is higher in descending thoracic aortas than aortic arches of C57BL6 mice
Another study by Zhang and colleagues demonstrate that endothelial specific over-expression of SIRT1 decreases atherosclerosis in ApoE-/- mice[12]
Summary
It is of note that at early to middle stages of atherosclerosis and advanced age, eNOS protein level in the vasculature is not decreased and even upregulated[6,7]. The relationship between SIRT1-eNOS signaling and atherosclerosis has been implicated recently by Chen and colleagues[11], who show that SIRT1 level is higher in descending thoracic aortas (atherosclerotic resistant region) than aortic arches (atherosclerotic prone region) of C57BL6 mice. Another study by Zhang and colleagues demonstrate that endothelial specific over-expression of SIRT1 decreases atherosclerosis in ApoE-/- mice[12].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
