The vaporization enthalpies and vapor pressures of Vescepa® and related unsaturated marine FAME by correlation gas chromatography

Abstract

This article combines data from two previous reports together with new data dealing with the vaporization enthalpies and vapor pressures of a series of saturated and unsaturated fatty acid methyl ester(s) (FAME) by correlation gas chromatography. The work updates earlier results using newly proposed vaporization enthalpies for the saturated FAME used as standards in previous work. This update also provides some insight into the requirements necessary for appropriate column and standard selection for experiments using correlation gas chromatography. Vaporization enthalpies and vapor pressures for saturated FAME methyl heneicosanoate, methyl docosanoate, and methyl tetracosanoate are re-evaluated and together with proposed literature values for methyl tetradecanoate to methyl eicosanoate, are used to evaluate similar properties for a series of unsaturated fatty acid esters. Updated results on the vaporization enthalpies and vapor pressures of a number of unsaturated fatty acid methyl esters (FAME) found in marine oil are reported including several relatively reactive omega-3-polyunsaturated esters. Omega-3-FAME include methyl (9,12,15)Z-octadecatrienoate, methyl (5,8,11,14,17)Z-eicosapentaenoate, and methyl (4,7,10,13,16,19)Z-docosahexenoate among other unsaturated methyl esters. Also included in the study of the omega-3-unsaturated esters is the drug Vescepa®, ethyl (5,8,11,14,17)Z-eicosapentaenoate, a drug used to lower triglyceride levels.