The value of rapid semi-automated morphometric analysis system in predicting malignancy in thyroid follicular neoplasm

Abstract

To constuct and evaluate a rapid semiautomated system in discriminating malignant from benign follicular thyroid neoplasms.Sixty formalin fixed paraffin embeded blocksof follicular thyroid neoplasms were retreived and slides were prepared and H and E stained. A morphometric system was constructed to be as rapid as possible and was tested. No signficant difference was found in ratio of largest nuclear to smallest nuclear diameter between follicualr adenoma and follicualr carcinoma groups. Rapid semiautomated morphometric analysis is of no help in predicting malignancy in follicular thyroid neoplasm.