The value of presepsin(sCD-14) combined with NEWS for predicting the prognosis of patients with sepsis

Abstract

Objective To investigate the value of serum soluble leukocyte differentiation antigen 14 subtype (sCD14-ST, presepsin) combined with national early warning score (NEWS) for predicting the prognosis of emergency patients with sepsis. Methods To select 119 patients who came to the emergency department of Beijing Hospital with sepsis from September 2009 to July 2015 as the objects of the study. The serum samples were collected immediately as they came, the presepsin was measured, and the NEWS scorescalculated. Patients were divided into survival group (81 cases) and death group (38 cases) according to the 30-day prognosis, and the value of the presepsin, NEWS score and presepsin + NEWS score in the assessment of prognosis were compared. Results Presepsin and NEWS scores both were higher in the death group than the survival group.Presepsin and NEWS were the independent risk factors of the 30-day mortality of patients with sepsis.Under the ROC curve area (AUC) of presepsin and NEWS were 0.842 and 0.823; the combination of Presepsin and NEWS was 0.906. When presepsin> 927.5 pg / mL and NEWS> 6.5 points, it can significantly improve the efficacy of predicting prognosis. Conclusions Serum presepsin is a good indicator to judge the prognosis of patients with sepsis, and the combination with NEWS can improve the ability to predict the risk of septic death. Key words: Sepsis; Presepsin; NEWS; Prognosis