Abstract
Abstract Background Female pattern hair loss (FPHL) is the most common cause of non- scaring alopecia in females and it significantly affects individuals' overall quality of life. Managing this condition poses a regular challenge in dermatological practice due to the limited supporting evidence for many therapeutic options, frequently resulting in unmet patient expectations. Nanofat grafts, generated by emulsification and filtering of microfat, contain growth factors and Adipose Derived Stem Cells (ADSCs) that can induce tissue regeneration and improve tissue quality Objective To assess the efficacy of Platelets Rich Plasma (PRP) added to Nanofat in Female Pattern Hair Loss (FPHL) Methods This is an Interventional study, which included 20 female patients with female pattern hair loss (FPHL) after exclusion of other causes of alopecia. Patients were selected from the outpatient clinic of Dermatology of Ain Shams University Hospitals from December 2022 till May 2023. Results In our study, 20 FPHL patients aging from 18 to 50 years. They were treated by Nanofat with PRP. They were followed up at12 and 24 weeks clinically by photography and trichoscopically by counting terminal and vellus hair and assessing the change in terminal and vellus hair thickness which were analyzed using image J data analysis software. Mean terminal hair count was increased highly significantly in number, as it increased from 73.90 hair/cm2 before treatment to 120.05 hair/cm2. There were high statistically significant decrease in vellus hair count, decreased from 46.60 to 25.20 (p < 0.001). There was high statistically significant increase in terminal hair thickness after treatment from 0.044 to 0.062 after 6months, (p < 0.001). There was high statistically significant increase in vellus hair thickness after treatment from 0.020 to 0.026 after 6 months from 0.020 to 0.023, p < 0.001 Conclusion The procedure seems safe, effective, well-tolerated by all the patients with encouraging response from these patients. We observed no adverse side effects in any. patient
Published Version
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