The Value of IL-25, IL-33, and TSLP in Nasal Secretions as a Biomarker of Severity of Allergic Rhinitis in Children

Abstract

Epithelial-derived cytokines such as IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) play critical roles in allergic rhinitis (AR) inflammation. These cytokines are produced as the first line of defense against infection and irritation of the airway epithelium, are mainly involved in type 2 inflammatory responses, and are important regulators linking innate and adaptive immunity. We hypothesized that severity of allergic rhinitis (AR) in children would be associated with increased levels of these cytokines in nasal secretions.