The value of early diagnosis of acute myocardial infarction of the high-sensitivity Troponin I assay on the Atellica analyzer

Abstract

Laboratory tests play an extremely important role in the diagnosis of acute myocardial infarction (MI), helping clinicians to make early decisions on patients with suspected MI. Thereby helping to increase the effectiveness of treatment, reduce the rate of complications after MI, and increase the survival rate of MI patients. Troponin is a component of the muscle contraction complex, which has been used as a diagnostic marker of MI in clinical practice with the high-sensitivity Troponin T and Troponin I types. At Hanoi Medical University Hospital, before deploying the high-sensitivity Troponin I assay, validation was conducted to compare the performance of the method surveyed by the laboratory with the manufacturer’s announcements. And especially investigating the diagnostic value of acute coronary syndromes of the high-sensitivity Troponin I assay. Validation results of the high-sensitivity troponin I test method all meet the standards of the Clinical and Laboratory Standards Institute (CLSI) and the manufacturer’s announcement. The sensitivity, specificity and area under the curve (AUC) of the high-sensitivity Troponin I assay on the Atellica analyzer were 90.2, 78.7, and 0.881%, respectively. Thus, the technical characteristics of the high-sensitivity Troponin I assay with precision, accuracy, linear range, LoD, and LoQ meet the standards of CLSI and the manufacturer. The study has demonstrated the effectiveness of the high-sensitivity Troponin I assay in the diagnosis and prognosis of acute MI.