Abstract
Abstract Background Early-onset sepsis (EOS) remains a common and serious problem in neonates. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are easily accessible biomarkers that have been reported to have meaningful correlations with inflammatory markers. Objectives We aimed to evaluate the NLR, PLR and systemic immune-inflammation (SII) as a diagnostic tests for early detection of EOS. Patients and Methods This study was carried out on 100 preterm infants at the Neonatal Intensive Care Unit (NICU) of Ain Shams University Children’s Hospital. They were divided into two groups: Group A (patient group) which included 45 preterm, suffering from EOS and group B (controls group) which included 55 healthy preterm. History-taking, complete clinical examination, blood culture, complete blood count (CBC), C-reactive protein (CRP), NLR, PLR and SII were done. Results Patients group (high CRP, Rodwell Score positive, positive blood cultures) had significantly higher NLR, PLR, and SII at first and third day of life compared with the controls group(negative CRP, Rodwell Score non sepsis and negative blood cultures). NLR of 1.9 was determined as the predictive cutoff value of EOS (sensitivity 91.11%; specificity 92.73%). A PLR of 53.79 was determined as the predictive cutoff value of neonatal EOS (sensitivity 93.33%; specificity 43.64%). A SII of 333.97 was determined as the predictive cutoff value of neonatal EOS (sensitivity 97.98%; specificity 90.91%). Conclusion NLR, PLR and SII had high sensitivity and specificity as diagnostic markers for earlyonset neonatal sepsis.
Published Version
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