The value of asphericity derived from T1-weighted MR in differentiating intraparenchymal ring-enhancing lesions-comparison of glioblastomas and brain abscesses.

Abstract

Both brain abscess(BA)and glioblastoma (GBM) are common causative pathologies of intraparenchymal ring-enhancing lesions. Advanced MR sequences such as diffusion weighted image (DWI) were often used to increase distinguishability of both entities. To evaluate the value of asphericity (ASP) from conventional T1-weighted MR images in differentiating BA from morphologically similar ring-enhancing GBM. Twenty-one BA and twenty-nine GBM were retrospectively included in this study. Each region of interest (ROI) was delineated twice with the software of ITK-SNAP on the contrast-enhanced T1 images by two observers. ASP was calculated to define the relative deviation of the ROI's shape from a sphere. Intraclass correlation coefficients (ICC) for inter-observer and intra-observer were calculated. The diagnostic capabilities of ASP and conventional volume (VOL) of ROI were evaluated with receiver operating characteristic (ROC) curve analysis. In addition, areas under the ROC curves of ASP and VOL were compared. ICC of intra-observer and inter-observer were 0.99 (95% confidence interval, [CI] 0.97-0.99) and 0.98 (0.95-0.99), respectively. Both ASP and VOL showed significant difference between BA and GBM. The mean ASP values for BA and GBM were 66.3±7.8 and 14.7±1.8, respectively. The mean VOL value of BA was also larger than that of GBM (47.2±7.4 vs. 20.7±1.5 mm3). The mean AUC of ASP and VOL were 0.977 (95% CI 0.944-1) and 0.86 (95% CI 0.746-0.974), respectively. The AUC of ASP was significantly higher than that of VOL (p=0.04). The optimal cut point values of ASP and VOL were 24.39 and 24.86 mm3, respectively. ASP derived from routine MRI is useful in differentiating BA from GBM.