The value of area curve ratio electrocochleography in diagnosisof Meniere's disease during different periods

Abstract

Objective:To evaluate the value of summating potential /action potential (SP/AP) area curve ratio in diagnosis of Meniere s disease(MD) during acute attacks and quiescence phase.Method:The normal control group and the MD group during acute attacks and quiescence phase received electrocochleography(EcochG)examination.The SP/AP amplitude and area curve ratios were measured respectively(to derive the SP/AP amplitude and area curve ratio),with normal SP/AP amplitude and area curve ratios of EcochG were identified,and analysed the results of EcochG in MD acute attacks and MD quiescence phase and the normal control group.Result:The upper limit of normal for SP/AP amplitude and area curve ratio were respectively 0.40 and 1.78.The SP/AP area curve ratio positive rate during acute attacks was 95.56% and SP/AP amplitude ratio was 71.77%.SP/AP area curve ratio positive rate during quiescence phase was 55.56% and amplitude ratio was 33.33%.The results showed that there were significant different between the two markers(P<0.05).The positive rate which during the period of acute attacks was higher than that quiescence phase period,The positive rate of the SP/AP amplitude and area curve ratios between acute attacks and quiescence phase were significant different(P<0.05).By the F rest,the SP/AP area curve ratio parameters in MD acute attacks and MD quiescence phase and the normal control group were compared,and the difference was significant(F=111.10,P<0.05).There were significant different between the two groups among three(P<0.05).The SP/AP area curve ratio parameters among the MD acute attacks and MD quiescence phase and the normal control group were significant different(F=65.68,P<0.05).There were significant different between the two groups among three(P<0.05).Conclusion:It can increase the positive rate when undergo the EcochG examination during acute attacks of Meniere's disease,while the SP/AP area curve measures are more sensitive than SP/AP amplitude ratio in diagnosis of Meniere's disease.