Abstract
The activities of 3-oxo acid-CoA transferase (EC 2.8.3.5, 13–15 μmol/min per g) and acetoacetyl-CoA thiolase (EC 2.3.1.9, 18–21 μmol/min per g) in interscapular brown adipose tissue of the rat are comparable to the activities reported for heart and kidney. The incorporation of d-3-hydroxy[3- 14C]butyrate into lipid in vivo was about 30-fold higher in interscapular brown adipose tissue than in white adipose tissue of virgin rats. In lactating rats, the mammary gland was the major site of ketone body incoporation into lipid and incorporation of d-3-hydroxy-[3- 14C]butyrate into lipid in brown adipose tissue was lower than in virgin rats. After an oral load of mediumchain triacylglycerol, which inhibits lipogenesis in lactating mammary gland, the incorporation of ketone bodies into lipid was decreased in mammary gland but increased in brown adipose tissue. The rate of oxidation of d-3-hydroxy[3- 14C]butyrate by brown adipose tissue slices in vitro was higher than the rate of incorporation into lipid.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
