Abstract
The usual SASPects of liver cancer.
Highlights
Cellular senescence is a stable form of cell cycle arrest that limits the propagation of damaged cells and can be triggered in response to diverse forms of cellular stress [1]
Both the innate and the adaptive immune systems were involved in the elimination of pre-malignant senescent hepatocytes, suggesting that different senescence triggers could provoke diverse immune responses
Activated hepatic stellate cells (HSCs) eventually undergo cellular senescence and produce a senescenceassociated secretory phenotype (SASP) enriched in fibrolytic molecules, contributing to fibrosis resolution [4]
Summary
Cellular senescence is a stable form of cell cycle arrest that limits the propagation of damaged cells and can be triggered in response to diverse forms of cellular stress [1]. More recent data showed that oncogenic Nras-induced hepatocyte senescence followed by senescence surveillance acts as an efficient barrier to liver tumorigenesis [3]. Cellular senescence can be triggered in the stromal compartment of the liver. Hepatic stellate cells (HSCs) activate, proliferate, and develop a profibrotic secretome.
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