Abstract
Aim: The use of stem cells in dental implant site development Methods: A total of 15 patients were enrolled and divided into three groups, with each group receiving 1x105, 1x106, and 1x107 stem cell treatment dosages. Following treatment, CT scan was done to measure their bone mineral density (BMD), which was scored using Hounsfield units (HU) grading. Tests were performed prior to treatment, as well as 4,6,8,12 weeks after dental implantation to determine the success of the procedure. Results: There were no major side effects over the six-month study period. There was no association identified between the stem cell transplant and any of the side effects Multiplex immunological tests were used to determine the amount of cytokines and chemokines present in the subjects. The inflammatory markers eotaxin, FGF2, MCP-1, MDC, and IL17a were elevated in patients treated with stem cells. Stem cells secrete cytokines and chemokines that aid in the healing of damaged tissue. Conclusions: Stem cell treatment for dental implantation is well tolerated and has no significant negative effects. Keywords: Stem cell, dental implantation
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