Abstract
Porous sol-gel glass was used as a prolonged delivery system for progesterone. Cylindrical rods doped with [3H]progesterone were implanted subcutaneously into adult male Wistar rats. The release rate was determined by measuring the blood radioactivity using scintillation technique. The implants were removed from the animals and put into pure alcohol to determine the amount of steroid remaining in the sol-gel glass. It was found that following a short initial burst effect, the release rate was nearly constant for over four weeks. The results suggest that the design of the porous sol-gel glass implants described in this study provides a useful method for prolonged delivery of progesterone.
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