Abstract
Solid dispersions of active pharmaceutical ingredients (APIs) in freely water soluble carriers are often used in order to improve dissolution rate and/or solubility of poorly water soluble drugs [1] in the aqueous gastro intestinal fluids. [...]
Highlights
Solid dispersions of active pharmaceutical ingredients (APIs) in freely water soluble carriers are often used in order to improve dissolution rate and/or solubility of poorly water soluble drugs [1] in the aqueous gastro intestinal fluids
Depending on the dispersion of the drug in the carrier one may distinguish between solid solutions, in which the drug is molecularly dispersed within the carrier and solid suspensions, which is a dispersion of either amorphous or crystalline drug particles in the carrier
Storage may lead to changes in the dispersion of the drug in the carrier, for example leading to the recrystallisation of initially dissolved API in the carrier
Summary
Solid dispersions of active pharmaceutical ingredients (APIs) in freely water soluble carriers are often used in order to improve dissolution rate and/or solubility of poorly water soluble drugs [1] in the aqueous gastro intestinal fluids. 1 Research Center Pharmaceutical Engineering GmbH, Graz, Austria 2 Institut of Biophysics and X-Ray Structure Research, Austrian Academy of Sciences, Graz, Austria 3 HECUS X-Ray Systems, Graz, Austria 4 Institute for Process and Particle Engineering, Graz University of technology, Graz, Austria
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