Abstract
目的 观察微泵静注丙泊酚复合亚麻醉剂量氯胺酮清醒镇静用于甲状腺手术中的临床效果.方法 选择ASA Ⅰ～Ⅱ级的甲状腺手术患者60例,随机分为4组,每组15例.分别在丙泊酚20ml溶液中加入氯胺酮0mg(Ⅰ组,对照组),50mg(Ⅱ组),100 mg(Ⅲ组),150mg(Ⅳ组).以首次静脉推注丙泊酚剂量50 ug/kg后,继之以微泵输注35ug/kg/min维持,监测血压、心率、SpO2、ECG、警觉/镇静(0从/S)评分及药物不良反应.结果 试验组病人术中镇静效果较对照组满意(P＜0.05),Ⅲ组病人随访满意度最高(P＜0.05),而Ⅳ组不良反应发生率明显增加(P＜0.05).结论 颈丛麻醉下行甲状腺手术时,丙泊酚复合亚麻醉剂量氯胺酮清醒镇静效果优于单纯应用丙泊酚,100 mg组氯胺酮复合丙泊酚是较为合适的配伍剂量。
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