Abstract
Abstract. Bone repair has been a challenging issue for a long time. Some recent studies focused on the incorporation of metallic elements into scafffolds for improving the performance for bone regeneration. This review explores the use of metallic elements in bone repair scaffolds, focusing on strontium (Sr), silicon (Si), magnesium (Mg) and Titanium (Ti). These elements enhance scaffold properties, promoting bone regeneration. Sr5(PO4)2SiO4 (SPS) bioceramic scaffolds, fabricated through 3D plotting and sol-gel methods, exhibit superior mechanical strength and induce osteogenesis and angiogenesis in vitro. Sr and Si ions within the SPS scaffolds upregulate genes related to cell proliferation, osteogenesis, and angiogenesis. Porous magnesium (Mg) scaffolds, with their biodegradability and ability to stimulate bone formation, offer an alternative to traditional metal implants. Mg scaffolds demonstrate good biocompatibility, physical properties, and osteoinductive potential. Porous titanium (Ti) scaffolds, manufactured through powder metallurgy, address the issue of stress shielding associated with conventional Ti implants. The interconnected pore network and controlled porosity of these scaffolds mimic natural bone, leading to improved biocompatibility and cell interaction.
Published Version
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