Abstract
The application of artificial intelligence in single molecule biophysical data analysis has not yet been adequately explored. To fill this gap, we have been developing multiple machine learning (ML) methods for single-molecule data analysis. Our lab uses bead loss assays (BLAs) in which micron sized beads are tethered with DNA and recorded using video microscopy to study DNA cleavage by type II restriction endonucleases. In a typical BLA, the addition of enzyme results in DNA cleavage and the loss of tethered beads.
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