The use of Levofloxacin and SUB-PRO in the treatment of bacterial haemorrhagic septicaemia in Cyprinids

Abstract

The aim was to determine the effective dosages of Levofloxacin, an antibacterial drug new for aquaculture, for the treatment of bacterial haemorrhagic septicaemia in carps and improvement of the physiological state of fish following disease and antibiotic therapy.The methods: the experiments were carried out in aquaculture on juvenile carps infected with a mixed culture of pathogens: highly pathogenic strains of Aeromonas sp., Acinetobacter calcoaceticus, and Citrobacter. Three dosages of Levofloxacin were tested: 250, 500, and 1,000 mg/kg of ichtyomass with feed for 7 days. After the antibiotic therapy, a course of feeding was carried out with SUB-PRO probiotic at a dose of 0.4 g/kg of feed for 10 days.Scientific novelty: application of a broad-spectrum antibiotic Levofloxacin, an antibacterial drug new for aquaculture, in fish.The results: positive results were obtained with Levofloxacin, an antibiotic new for aquaculture, in the treatment of bacterial haemorrhagic septicaemia. The advantage of the drug is the inhibitory effect on a wide range of bacterial agents and the absence of negative effects on the physiological state of fish. An effective dosage of Levofloxacin (1,000 mg/kg of ichtyomass for 7 days) was established under experimental conditions. The positive dynamics on the blood parameters of the probiotic drug “SUB-PRO” after the disease and antibiotic therapy was revealed, which provided an increase in the resistance of the fish organism.The practical significance: the findings will be crucial in the development of practical recommendations for the treatment of bacterial haemorrhagic septicaemia of fish in aquaculture.