Abstract
Hearts were removed from anesthetized guinea pigs and muskrats and were perfused with a buffer containing glucose, pyruvate, lactate, and palmitic acid under both working and nonworking conditions. The uptake of glucose and the release of lactate was greater in muskrat hearts than in guinea pig hearts under all conditions. The uptake of pyruvate was small in the hearts of both species but was significantly greater in guinea pig hearts. The oxidation of exogenous palmitic acid was similar under nonworking and low-level working conditions, but the guinea pig hearts oxidized more palmitic acid under the higher-level working conditions than did muskrat hearts. Under all working conditions the muskrat hearts failed to produce a cardiac output in excess of that required to supply their own coronary flow. Guinea pig hearts produce a cardiac output and a rise in left ventricular pressure. Mitochondrial function in the hearts of the two species was similar except that state 4 respiration rate in the muskrat heart ...
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