Abstract
A clinical experiment was carried out to study the effect of PGE1 (prostaglandin E1) on the isolated cat rabbit rat guinea pig and frog heart. Heart rate contraction and coronary flow were used as heart parameters in the study. Results showed differential effects of PGE1 on the different species. The effect was negative for cat and rabbit heart and modest in rat heart. On the other hand under the experimental conditions the effect of PGE1 on guinea pig and frog heart was strong. Effects on all the species are illustrated graphically. In the guinea pig a 1 ug dose of PGE1 caused a 10-minute increase in heart rate and increased heart contraction and coronary blood flow. The effects of PGE1 on the guinea pig heart were not prevented by beta-receptor blocking agents perfusion of Nethalide. The PGE1 effect on the frog heart was a long-lasting positive inotropic effect similar to that of adrenaline. The mechanism of the pronounced PGE1 action on the guinea pig and frog heart is still unknown. (Summaries in GER FRE)
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Schedule a callMore From: Medicina et pharmacologia experimentalis. International journal of experimental medicine
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