Abstract
The purpose of the work is to evaluate the efficacy and tolerance of extemporal dosage form with pyroctone olamine in the local treatment of patients with seborrheic dermatitis. Under our supervision there were 78 patients with seborrheic dermatitis aged 18 to 57 years. The average age of the patients was 29.5±2.1 years. Comprehensive treatment of patients with seborrheic dermatitis in both groups depended on the severity of clinical manifestations, the duration of the disease, and information on the effectiveness of previous therapy. For external treatment of the main group of patients with seborrheic dermatitis, an extemporaneously prepared gel with pyrocton olamine was used. Local treatment of patients in the comparison group consisted of the appointment of 1% cream of clotrimazole. An analysis of the results shows good therapeutic, microbiological effectiveness and good tolerance of extemporaneously prepared gel with pyrocton olamine in the complex treatment of patients with seborrheic dermatitis. The period for resolving the clinical manifestations of seborrheic dermatitis among patients in the main group was 2.5±0.1 days shorter compared with patients in the comparison group. The intensity of clinical manifestations in patients with seborrheic dermatitis of the main group decreased twice on the second day of complex treatment. In control patients with comparative seborrheic dermatitis, similar therapeutic efficacy was achieved on the fourth to fifth day. Long-term results of the study showed that the recurrence of the disease among patients of the main group was 5 (6.4%), and in patients of in the comparison group was 14 (17.9%). Clinical studies have shown good therapeutic efficacy and tolerance of the extemporal gel with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis, which gives reason to recommend this dosage form for wider use in the practice of dermatovenerologists.
Highlights
Клінічне дослідження показало хорошу терапевтичну ефективність і переносимість екстемпорального гелю з піроктон оламіном у комплексному лікуванні хворих на себорейний дерматит, що дає підставу рекомендувати цю лікарську форму для більш широкого застосування в практиці лікарів-дерматовенерологів
In seborrheic dermatitis the pathological process in the form of erythematous-squamous rashes is localized on hairy part of the scalp and trunk which anatomically have a large number of sebaceous glands
Formed fungi and microorganisms associations lead to an inflammatory process with the formation of various clinical manifestations of seborrheic dermatitis
Summary
Клінічне дослідження показало хорошу терапевтичну ефективність і переносимість екстемпорального гелю з піроктон оламіном у комплексному лікуванні хворих на себорейний дерматит, що дає підставу рекомендувати цю лікарську форму для більш широкого застосування в практиці лікарів-дерматовенерологів. Seborrheic dermatitis is one of the most common chronic inflammatory diseases, accompanied by a change in the quantitative and qualitative sebum composition, which contributes to the impairment of microbial landscape of skin and activity of saprophytic microorganisms. In seborrheic dermatitis the pathological process in the form of erythematous-squamous rashes is localized on hairy part of the scalp and trunk which anatomically have a large number of sebaceous glands. The cause and development mechanisms of seborrheic dermatitis are multifaceted and not completely studied. One of the main pathogenetic mechanisms of seborrheic dermatitis is the Malassezia activation with the formation of complex microbial associations. Malassezia is a formation leader of fungi and microorganisms associations in the lesions with seborrheic dermatitis. Formed fungi and microorganisms associations lead to an inflammatory process with the formation of various clinical manifestations of seborrheic dermatitis. The activation of opportunistic pathogenic microorganisms on the skin in seborrheic dermatitis is evidenced by the higher contamination frequency of the affected scalp areas with S. capitis, Micrococcus spp., Acinetobacter spp. etc. [6, 8, 9, 10]
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